Single-nucleotide polymorphisms in genes involved in folate metabolism or selected other metabolites and risk for gestational diabetes mellitus

Table 3 Gene-gene interaction models of 18 single-nucleotide polymorphisms and their association with gestational diabetes mellitus risk

Number of sites	The best model	Tr.BA1	Te.BA2	P value	CVC3
1	rs10830963	0.5599	0.5599	0.055	10/10
2	rs10830963 rs4721	0.5999	0.5996	0.001	10/10
3	rs10830963 rs4721 rs1801131	0.6219	0.5490	0.172	5/10
4	rs10830963 rs4721 rs1801131 rs5015480	0.6587	0.5420	0.623	4/10
5	rs10830963 rs4721 rs1801131 rs5015480 rs7756992	0.7229	0.4798	0.828	2/10

¹Training Bal.Acc, training balanced accuracy, the accuracy in the training set, with a range of 0-1, where the larger the value, the higher the accuracy.

²Testing Bal.Acc, testing balanced accuracy, the accuracy in the testing set, with a range of 0-1, where the larger the value, the higher the accuracy.

³Cross-verifying consistency.

CVC: Cross-validation consistency.