Single-nucleotide polymorphisms in genes involved in folate metabolism or selected other metabolites and risk for gestational diabetes mellitus

Table 2 Allele frequencies of single-nucleotide polymorphisms in the case and control groups, n (%)

Gene	SNP	Allele	GDM	Control	χ2	P value	Padjusted1
RFC-1	rs1051266	T	361 (44.0)	362 (44.1)	0.002	0.960	0.963
		C	459 (56.0)	458 (55.9)
MTHFR	rs1801131	G	116 (14.1)	129 (15.7)	0.810	0.368	0.694
		T	708 (85.9)	695 (84.3)
	rs1801133	G	364 (44.3)	378 (46.0)	0.481	0.488	0.694
		A	458 (55.7)	444 (54.0)
	rs2274976	T	46 (5.6)	54 (6.6)	0.661	0.416	0.694
		C	776 (94.4)	770 (93.4)
MTRR	rs1801394	G	217 (26.4)	202 (24.8)	0.581	0.446	0.694
		A	605 (73.6)	614 (75.2)
DHFR	rs408626	T	321 (39.1)	320 (38.8)	0.008	0.928	0.963
		C	501 (60.9)	504 (61.2)
MTR	rs1805087	G	69 (8.4)	85 (10.3)	1.791	0.181	0.542
		A	753 (91.6)	739 (89.7)
SHMT1	rs1979277	A	45 (5.5)	60 (7.3)	2.289	0.130	0.535
		G	779 (94.5)	764 (92.7)
GCP II	rs202676	G	282 (34.4)	253 (30.9)	2.333	0.127	0.535
		A	538 (65.6)	567 (69.1)
MTHFD1	rs2236225	A	193 (23.5)	196 (23.8)	0.014	0.905	0.963
		G	627 (76.5)	628 (76.2)
ADIPOQ	rs2241766	G	207 (25.2)	220 (26.7)	0.453	0.501	0.694
		T	613 (74.8)	604 (73.3)
	rs266729	G	213 (26.2)	212 (25.9)	0.030	0.862	0.963
		C	599 (73.8)	608 (74.1)
MTNR1B	rs10830963	G	389 (47.6)	317 (38.6)	13.517	< 0.001	0.004
		C	429 (52.4)	505 (61.4)
	rs1387153	T	368 (44.9)	322 (39.2)	5.484	0.019	0.173
		C	452 (55.1)	500 (60.8)
CDKAL1	rs7756992	A	395 (48.3)	396 (48.2)	0.002	0.963	0.963
		G	423 (51.7)	426 (51.8)
PPARG	rs1801282	G	53 (6.5)	65 (7.9)	1.253	0.263	0.676
		C	767 (93.5)	759 (92.1)
Chemerin	rs4721	G	367 (44.8)	387 (47.1)	0.893	0.345	0.694
		T	453 (55.2)	435 (52.9)
HHEX	rs5015480	C	156 (18.9)	133 (16.2)	2.087	0.149	0.535
	T	668 (81.1)	687 (83.8)

¹The P value was corrected using the Benjamini-Hochberg method.

SNP: Single-nucleotide polymorphism; GDM: Gestational diabetes mellitus.