Shenfushu granules attenuate diabetic kidney disease by inhibiting PIK3R1/protein kinase B/heparanase-mediated endothelial-mesenchymal transition

Figure 1 Shenfushu granules delay the progression of diabetic kidney disease. A: Body weight; B: Kidney weight/body weight; C: Serum creatinine level; D: Blood urea nitrogen level; E: 24-hour albuminuria level; F: Albumin/urine creatinine ratio; G: Urine volume; H: Blood glucose level. The data are presented as the mean ± SE (n = 8). ^aP < 0.05. ^bP < 0.01. ^cP < 0.001. ¹P vs control group. ²P vs model group. KW: Kidney weight; BW: Body weight; BUN: Blood urea nitrogen; ACR: Albumin/urine creatinine ratio; SFSGs: Shenfushu granules; L: Low; M: Middle; H: High.