Comparisons of various insulin resistance indices for new-onset metabolic syndrome before midlife: The CHIEF cohort study, 2014-2020

Table 4 Sex-specific receiver operating characteristic curve analysis of various non-insulin-based insulin resistance indices for incidence of metabolic syndrome

	Men			Women			P value between men and women
	AUC	95%CI	P value	AUC	95%CI	P value
METS-IR index	0.771	0.751-0.792	Reference	0.764	0.654-0.874	Reference	0.001
TyG index	0.726	0.704-0.748	0.002	0.693	0.575-0.812	0.39	0.001
ALT/AST	0.657	0.633-0.681	< 0.001	0.718	0.614-0.822	0.55	0.001
TC/HDL-C	0.715	0.692-0.738	< 0.001	0.793	0.684-0.901	0.71	0.001
TG/HDL-C	0.741	0.719-0.762	0.04	0.723	0.598-0.848	0.62	0.001
ZJU index	0.734	0.712-0.756	0.01	0.751	0.658-0.844	0.85	0.001

Receiver operating characteristic curve analysis was used to determine the area under curve with adjustments for age, sex, alcohol consumption status, tobacco smoking status, physical activity levels, and waist circumference. AUC: Area under curve; METS-IR: Metabolic score for insulin resistance; TyG: Triglyceride glucose; ALT: Alanine transaminase; AST: Aspartate transaminase; TC: Total cholesterol; HDL-C: High-density lipoprotein cholesterol; TG: Triglyceride; ZJU: Zhejiang University.