Comparisons of various insulin resistance indices for new-onset metabolic syndrome before midlife: The CHIEF cohort study, 2014-2020

Table 2 Associations between various non-insulin-based insulin resistance indices and incident metabolic syndrome

	Model 1			Model 2
	HR	95%CI	P value	HR	95%CI	P value
METS-IR index	78.937	55.157-112.970	< 0.001	32.996	21.706-50.158	< 0.001
TyG index	3.671	3.231-4.172	< 0.001	2.602	2.259-2.997	< 0.001
ALT/AST	2.824	2.421-3.294	< 0.001	1.495	1.238-1.804	< 0.001
TC/HDL-C	1.923	1.801-2.053	< 0.001	1.606	1.489-1.731	< 0.001
TG/HDL-C	1.250	1.222-1.278	< 0.001	1.187	1.157-1.219	< 0.001
ZJU index	1.028	1.025-1.031	< 0.001	1.023	1.019-1.027	< 0.001

Multivariable Cox regression analysis was used to determine the associations with adjustments for age, sex, alcohol consumption status, tobacco smoking status, and physical activity levels in model 1 and further adjustment for waist circumference in model 2. METS-IR: Metabolic score for insulin resistance; TyG: Triglyceride glucose; ALT: Alanine transaminase; AST: Aspartate transaminase; TC: Total cholesterol; HDL-C: High-density lipoprotein cholesterol; TG: Triglyceride; ZJU: Zhejiang University.