Zebrafish as a preclinical model for diabetes mellitus and its complications: From monogenic to gestational diabetes and beyond

Table 2 Applications of zebrafish model in diabetes

Types of diabetes	Advantages	Disadvantages	Ref.
T1DM	High degree of similarity to the human pancreas and most genes have been deciphered by the human body; it compensates for the shortcomings of rodents, such as high reproductive rate	Zebrafish are variable temperature animals and it is difficult to measure their insulin content	[77,79,99]
T2DM
Monogenic diabetes		There have been few studies on monogenic diabetes based on the zebrafish model
GDM	For assessing the health status of infants born to mothers with a history of diabetes or gestational diabetes	There have been few studies on pregnancy diabetes with zebrafish as the model	[76]

T1DM: Type 1 diabetes mellitus; T2DM: Type 2 diabetes mellitus; GDM: Gestational diabetes mellitus.