Curcumol ameliorates diabetic retinopathy via modulating fat mass and obesity-associated protein-demethylated MAF transcription factor G antisense RNA 1

Figure 2 Curcumol inhibits high glucose-induced proliferation, migration, and inflammation in human retinal vascular endothelial cells. A: Methyl tetrazolium assay was used to measure the proliferation of high glucose (HG)-treated human retinal vascular endothelial cells under different doses of curcumol; B and C: Cell colony assay to detect cell viability; D and E: Transwell migration assay to evaluate cell migration level; F and G: Levels of lactate dehydrogenase and malondialdehyde, both indicative of HG-induced cellular injury, were detected upon treatment with curcumol; H-J: The expressions of HG-induced transcription of inflammatory cytokines upon curcumol treatment were detected by quantitative real-time polymerase chain reaction. Data represent the mean ± SD. ^aP < 0.05, ^bP < 0.01, ^cP < 0.001. HG: High glucose; Cur: Curcumol; LDH: Lactate dehydrogenase; MDA: Malondialdehyde; TNF: Tumor necrosis factor; IL: Interleukin.