B-type natriuretic peptide efficacy compared to fragmented QRS for diastolic dysfunction screening in patients with type 2 diabetes

Figure 1 Receiver operating characteristic curves. A: B-type natriuretic peptide (BNP) level and the presence of left ventricular diastolic dysfunction (LVDD). The non-overweight group (closed circles, n = 163) has an area under the receiver operating characteristic (ROC) curve (AUC) threshold of 0.70 [95% confidence interval (CI): 0.61-0.79] threshold of 34.8 pg/mL. Overweight group (crosses, n = 140): AUC: 0.55 (95%CI: 0.43-0.66) threshold 7.2 pg/mL; B: Non-overweight group ROC curves of fragmented QRS (fQRS) and BNP with various cut-offs and the presence of LVDD. BNP (black closed circles, AUC: 0.70), BNP at a cut-off of 18.4 pg/mL (blue long dashed line, AUC: 0.66), BNP at a cut-off of 35 pg/mL (blue long dashed line, AUC: 0.69), BNP at a cut-off of 50 pg/mL (purple dotted dashed line, AUC: 0.62), and fQRS (red solid line, AUC: 0.63); C: Overweight group ROC curves of BNP (black crosses, AUC: 0.55), BNP at a cut-off of 18.4 pg/mL (green dotted line, AUC: 0.52), BNP at a cut-off of 35 pg/mL (blue long dashed line, AUC: 0.52), BNP at a cut-off of 50 pg/mL (purple dotted dashed line, AUC: 0.55), and fQRS (red solid line, AUC: 0.67). AUC: Area under the receiver operating characteristic curve; BNP: B-type natriuretic peptide; fQRS: Fragmented QRS; CI: Confidence interval.