Characteristic dysbiosis in patients with type 2 diabetes and hyperuricemia, and the effect of empagliflozin on gut microbiota

Figure 2 The characteristics of the microbiomes in the empagliflozin intervention study. A: Partial least squares discrimination analysis was used to show the differences of microbiome structures, and the permutational multivariate analysis of variance test results based on Bray Curtis distance were labeled in the figure; B: Differences of microbiome co-abundance between groups were tested by the paired t test, and the threshold of significance was P < 0.05; C: The linear correlation between co-abundance group 1 and uric acid; D: Metabolic pathways related to the uric acid metabolism among the three groups; E: Kos related to the uric acid metabolism among the three groups. Differences were tested by the paired t test. ^aP < 0.05. ^bP < 0.01. PLS-DA: Partial least squares discrimination analysis; PERMANOVA: Permutational multivariate analysis of variance; BMI: Body mass index; CAG: Co-abundance group.