Effect of systolic blood pressure status on coronary inflammation and high-risk plaque characteristics

doi:10.4239/wjd.v16.i4.102751

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World Journal of Diabetes

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1948-9358

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Diabetes. Apr 15, 2025; 16(4): 102751
Published online Apr 15, 2025. doi: 10.4239/wjd.v16.i4.102751

Table 1 Clinical baseline characteristics of the normotension group, low systolic blood pressure variability group, and high systolic blood pressure variability group

Variables	Normotension group, n = 213	Low SBPV group, n = 334	High SBPV group, n = 334	P value
Baseline characteristic
Age (years)	58.24 ± 9.32	61.83 ± 10.19^a	65.03 ± 10.88^a^,^b	< 0.001
Male sex	90 (42.3)	164 (49.1)	193 (57.8)^a^,^b	0.001
Body mass index (kg/m²)	23.71 ± 3.15	24.12 ± 3.13	24.73 ± 3.99^a	0.009
Smoking	33 (15.5)	57 (17.1)	71 (21.2)	0.187
Dyslipidemia	94 (44.1)	135 (40.4)	163(48.8)	0.115
Systolic pressure (mmHg)	118 ± 9	136 ± 10^a	149 ± 16^a^,^b	< 0.001
Diastolic pressure (mmHg)	73 ± 8	78 ± 11^a	85 ± 14^a^,^b	< 0.001
Laboratory findings
Fast glucose (mmol/L)	6.68 ± 2.87	7.66 ± 2.82	7.72 ± 3.93^a^,^b	0.005
HbA1c (%)	7.37 ± 2.36	7.42 ± 1.86^a	7.79 ± 1.97^a	0.027
Triglyceride (mmol/L)	1.36 (0.91, 1.82)	1.46 (0.81, 2.11)	1.55 (0.68, 2.41)^a^,^b	0.001
Total cholesterol (mmol/L)	4.41 ± 1.20	4.44 ± 1.19	4.64 ± 1.26^a	0.004
HDL-cholesterol (mmol/L)	1.25 ± 0.36	1.26 ± 0.35	1.28 ± 0.38^a^,^b	0.007
LDL-cholesterol (mmol/L)	2.59 ± 0.85	2.69 ± 0.95	2.79 ± 0.96^a^,^b	< 0.001
Lipid - lowering medication
Statin	128 (60.1)	214 (64.1)	261 (78.1)^a^,^b	0.001
Hypertension treatment
ARB/ACEI	-	128 (38.3)	82 (24.6)^b	< 0.001
Beta - blocker	-	87 (26.1)	65 (19.5)	0.064
Diuretics	-	27 (8.1)	22 (6.6)	0.830
Calcium channel blocker	-	119 (35.6)	163 (48.8)^b	0.001
Diabetes treatment
Oral	77 (36.1)	142 (42.5)	183 (54.8)^a^,^b	< 0.001
Insulin	36 (16.9)	57 (17.1)	70 (20.1)	0.192
Tube voltage of CT acquisition (kVp)				0.002
100	139 (65.3)	183 (54.8)	152 (45.5)
120	71 (33.4)	144 (43.1)	158 (47.3)
140	3 (1.4)	7 (2.1)	24 (7.2)

^aP < 0.005 vs the normotension group.

^bP < 0.005 vs the low systolic blood pressure variability group.

Data are showed as means ± SD, median (25^th and 75^th percentile), or n (%). SBPV: Systolic blood pressure variability; HbA1c: Glycated hemoglobin; LDL: Low-density lipoprotein; HDL: High-density lipoprotein; ARB/ACEI: Angiotensin receptor blockers/angiotensin-converting enzyme inhibitors; CT: Computed tomography.

Citation: Jiang CP, Liu YK, Cheng PP, Dong Y, Wang X, Wu FY, Xia YX, Wang PY, Xu XY. Effect of systolic blood pressure status on coronary inflammation and high-risk plaque characteristics. World J Diabetes 2025; 16(4): 102751
URL: https://www.wjgnet.com/1948-9358/full/v16/i4/102751.htm
DOI: https://dx.doi.org/10.4239/wjd.v16.i4.102751