Increased blood urea nitrogen levels and compromised peripheral nerve function in patients with type 2 diabetes

Table 5 Effects of blood urea nitrogen levels on sensory nerve function according to multivariable linear regression analysis

Models	B (95%CI)	β	t	P value	R2
Composite Z score of sensory latency
Model 0	0.123 (0.083, 0.163)	0.242	6.023	< 0.001	0.057
Model 1	0.052 (0.012, 0.091)	0.102	2.586	0.010	0.216
Model 2	0.065 (0.022, 0.108)	0.127	2.972	0.003	0.252
Model 3	0.063 (0.019, 0.106)	0.123	2.845	0.005	0.252
Composite Z score of sensory amplitude
Model 0	-0.141 (-0.182, -0.099)	-0.268	-6.698	< 0.001	0.070
Model 1	-0.056 (-0.095, -0.016)	-0.105	-2.763	0.006	0.269
Model 2	-0.080 (-0.122, -0.037)	-0.150	-3.668	< 0.001	0.319
Model 3	-0.076 (-0.118, -0.033)	-0.143	-3.495	< 0.001	0.331
Composite Z score of sensory NCV
Model 0	-0.116 (-0.156, -0.076)	-0.229	-5.670	< 0.001	0.051
Model 1	-0.050 (-0.090, -0.010)	-0.099	-2.449	0.015	0.188
Model 2	-0.061 (-0.104, -0.018)	-0.120	-2.786	0.006	0.242
Model 3	-0.059 (-0.102, -0.015)	-0.116	-2.660	0.008	0.241

Model 0: Unadjusted; Model 1: Adjusted for age, sex, diabetes duration, body mass index, systolic/diastolic blood pressure, hypertension and statin treatment; Model 2: Additionally adjusted for alanine aminotransferase, albumin, triglyceride, total cholesterol, uric acid, cystatin C, estimated glomerular filtration rate, albumin/creatinine ratio, C-peptide, hemoglobin and glycosylated hemoglobin A1c; Model 3: Additionally adjusted for hypoglycemic drugs. CI: Confidence interval; NCV: Nerve conduction velocity.