Increased blood urea nitrogen levels and compromised peripheral nerve function in patients with type 2 diabetes

Table 4 Effects of blood urea nitrogen levels on motor nerve function according to multivariable linear regression analysis

Models	B (95%CI)	β	t	P value	R2
Composite Z score of motor latency
Model 0	0.117 (0.082, 0.152)	0.266	6.651	< 0.001	0.069
Model 1	0.054 (0.019, 0.089)	0.122	3.056	0.002	0.197
Model 2	0.072 (0.034, 0.109)	0.160	3.772	< 0.001	0.266
Model 3	0.070 (0.032, 0.108)	0.155	3.623	< 0.001	0.262
Composite Z score of motor amplitude
Model 0	-0.112 (-0.142, -0.081)	-0.287	-7.224	< 0.001	0.081
Model 1	-0.054 (-0.084, -0.023)	-0.135	-3.393	< 0.001	0.209
Model 2	-0.078 (-0.112, -0.044)	-0.193	-4.491	< 0.001	0.243
Model 3	-0.076 (-0.110, -0.042)	-0.188	-4.395	< 0.001	0.263
Composite Z score of motor NCV
Model 0	-0.100 (-0.139, -0.060)	-0.202	-4.990	< 0.001	0.039
Model 1	-0.041 (-0.071, -0.011)	-0.060	-1.447	0.148	0.147
Model 2	-0.056 (-0.097, -0.014)	-0.110	-2.598	0.010	0.263
Model 3	-0.049 (-0.091, -0.007)	-0.098	-2.299	0.022	0.271

Model 0: Unadjusted; Model 1: Adjusted for age, sex, diabetes duration, body mass index, systolic/diastolic blood pressure, hypertension and statin treatment; Model 2: Additionally adjusted for alanine aminotransferase, albumin, triglyceride, total cholesterol, uric acid, cystatin C, estimated glomerular filtration rate, albumin/creatinine ratio, C-peptide, hemoglobin and glycosylated hemoglobin A1c; Model 3: Additionally adjusted for hypoglycemic drugs. CI: Confidence interval; NCV: Nerve conduction velocity.