Increased blood urea nitrogen levels and compromised peripheral nerve function in patients with type 2 diabetes

Table 3 Effects of blood urea nitrogen levels on overall peripheral nerve function according to multivariable linear regression analysis

Models	B (95%CI)	β	t	P value	R2
Overall composite Z-score for latency
Model 0	0.117 (0.085, 0.148)	0.288	7.263	< 0.001	0.081
Model 1	0.056 (0.024, 0.088)	0.137	3.433	< 0.001	0.196
Model 2	0.071 (0.036, 0.106)	0.172	4.032	< 0.001	0.257
Model 3	0.069 (0.034, 0.104)	0.166	3.864	< 0.001	0.256
Overall composite Z-score for amplitude
Model 0	-0.115 (-0.142, -0.088)	-0.325	-8.289	< 0.001	0.104
Model 1	-0.052 (-0.078, -0.025)	-0.142	-3.785	< 0.001	0.287
Model 2	-0.070 (-0.098, -0.041)	-0.193	-4.777	< 0.001	0.336
Model 3	-0.067 (-0.095, -0.038)	-0.184	-4.577	< 0.001	0.353
Overall composite Z-score for NCV
Model 0	-0.112 (-0.148, -0.076)	-0.243	-6.055	< 0.001	0.058
Model 1	-0.041 (-0.078, -0.004)	-0.087	-2.170	0.030	0.188
Model 2	-0.060 (-0.098, -0.021)	-0.126	-3.023	0.003	0.285
Model 3	-0.055 (-0.094, -0.016)	-0.117	-2.787	0.006	0.289

Model 0: Unadjusted; Model 1: Adjusted for age, sex, diabetes duration, body mass index, systolic/diastolic blood pressure, hypertension and statin treatment; Model 2: Additionally adjusted for alanine aminotransferase, albumin, triglyceride, total cholesterol, uric acid, cystatin C, estimated glomerular filtration rate, albumin/creatinine ratio, C-peptide, hemoglobin and glycosylated hemoglobin A1c; Model 3: Additionally adjusted for hypoglycemic drugs. CI: Confidence interval; NCV: Nerve conduction velocity.