Dl-3-n-butylphthalide ameliorates diabetic foot ulcer by inhibiting apoptosis and promoting angiogenesis

Figure 7 Molecular docking analysis and mRNA expression analysis of core genes. A: Molecular docking revealed the binding of Dl-3-n-butylphthalide to its targets. Blue solid line: Hydrogen bond; Gray dashed line: Hydrophobic interaction; Yellow dashed line: Electrostatic interaction; B: The quantitative real-time polymerase chain reaction analysis of the mRNA levels of heme oxygenase 1, caspase 3, B cell leukemia/lymphoma 2, brain derived neurotrophic factor and nuclear factor erythroid 2 L2. Data expressed as individual values with mean ± SD. ^bP < 0.01, ^aP < 0.05. HMOX: Heme oxygenase; CASP3: Caspase 3; BCL2: B cell leukemia/lymphoma 2; BDNF: Brain derived neurotrophic factor; NFE2: Nuclear factor erythroid 2; HG: High glucose; NBP: Dl-3-n-butylphthalide.