Dl-3-n-butylphthalide ameliorates diabetic foot ulcer by inhibiting apoptosis and promoting angiogenesis

Figure 6 Dl-3-n-butylphthalide exerts anti-apoptotic and anti-oxidative stress effects by modulating the advanced glycation end products-receptor of advanced glycation end products signaling pathway under high glucose conditions. A: Western blot analysis of the protein expression of advanced glycosylation end-product specific receptor; B: Flow cytometry analysis of reactive oxygen species levels; C and D: Kit-based detection of superoxide dismutase and malondialdehyde levels. Data expressed as individual values with mean ± SD. ^dP < 0.0001, ^cP < 0.001, ^bP < 0.01, ^aP < 0.05. AGER: Advanced glycosylation end-product specific receptor; HG: High glucose; NBP: Dl-3-n-butylphthalide.