Dl-3-n-butylphthalide ameliorates diabetic foot ulcer by inhibiting apoptosis and promoting angiogenesis

Figure 3 Dl-3-n-butylphthalide promotes cellular proliferation under high glucose conditions. A-C: Cell Counting Kit 8 assay was used to assess the effect of Dl-3-n-butylphthalide on cell proliferation; D: Edu assay showed the cell proliferation of human umbilical vein endothelial cells; E: Edu assay showed the cell proliferation of human keratinocytes cells; F: Edu assay showed the cell proliferation of human dermal fibroblasts; G: Quantification of Edu corporation assay in human umbilical vein endothelial cells, human keratinocytes cells, and human dermal fibroblasts. Data expressed as individual values with mean ± SE. ^dP < 0.0001, ^cP < 0.001, ^bP < 0.01, ^aP < 0.05, ^nsP > 0.05. HUVEC: Human umbilical vein endothelial cells; HaCaT: Human keratinocyte cells; HDF: Human dermal fibroblasts; HG: High glucose; NBP: Dl-3-n-butylphthalide.