Association between high-sensitivity troponin T levels below the ninety-ninth percentile and diabetic kidney disease: A cross-sectional study

Table 2 Association between high-sensitivity troponin T and diabetic kidney disease in patients with type 2 diabetes mellitus

Variable	DKD/total	Non-adjusted model	P value	Model I	P value	Model II	P value	Model III	P value
	n	HR (95%CI)		HR (95%CI)		HR (95%CI)		HR (95%CI)
Continuous variable
hs-troponin T (ng/L)	909/2505	1.11 (1.06-1.16)	< 0.001	1.11 (1.05-1.16)	< 0.001	1.08 (1.02-1.15)	0.017	1.07 (1.01-1.13)	0.030
Binary variable
Tertile 1 (< 5.93)	227/839	Reference	-	Reference	-	Reference	-	Refrence	-
Tertile 2 (5.94-9.79)	275/831	1.58 (1.00-2.48)	0.048	1.51 (0.91-2.50)	0.110	1.32 (0.82-2.13)	0.239	1.25 (0.77-2.02)	0.350
Tertile 3 (9.80-21.88)	407/835	3.02 (1.87-4.88)	< 0.001	2.80 (1.62-4.83)	< 0.001	2.30 (1.20-4.41)	0.015	2.07 (1.13-3.80)	0.022
P for trend	-	-	< 0.001	-	< 0.001	-	0.015	-	0.022

Model I: Adjusted for age (continuous) and sex (male or female); Model II: Adjusted for Model I plus race (Mexican American, non-Hispanic white, non-Hispanic black, Other Hispanic, other races including multi-racial), education level (< 9, 9-13, ≥ 13); body mass index (continuous), poverty income ratio (continuous), smoking status (never smoker, former smoker, current smoker), hypertension (no, yes), cardiovascular disease (no, yes), hyperlipidemia (no, yes), physical activity (inactive, active), alcohol intake (none, moderate, heavy), and estimated glomerular filtration rate(continuous); Model III: Adjusted for Model II plus diabetes duration (< 10 years, ≥ 10 years), use of diabetes medications (no, other, insulin, oral medications), healthy eating index (continuous), and glycated hemoglobin A1c (continuous); DKD: Diabetic kidney disease; HR: Hazard ratio; CI: Confidence interval; hs-troponin T: High-sensitivity troponin T.