NR4A1 silencing alleviates high-glucose-stimulated HK-2 cells pyroptosis and fibrosis via hindering NLRP3 activation and PI3K/AKT pathway

Figure 4 Markers of PI3K/AKT signaling pathway-mediated fibrosis were upregulated in rats with diabetic kidney disease. A: Representative western blotting and integrated density study of AKT, p-AKT, PI3K, and p-PI3K in rat kidney tissues; B: Representative western blotting and integrated density study of TGF-β1 and collagen III in rat kidney tissue, n = 3. ^aP < 0.05 vs control. AKT: Protein kinase B; CON: Control; DKD: Diabetic kidney disease; PI3K: Phosphoinositide 3-kinase; TGF-β1: Transforming growth factor β1.