NR4A1 silencing alleviates high-glucose-stimulated HK-2 cells pyroptosis and fibrosis via hindering NLRP3 activation and PI3K/AKT pathway

Figure 2 Nuclear receptor subfamily 4 group A member 1 expression was upregulated in kidney tissue of rats with diabetic kidney disease. A: Representative western blotting bands and integrated density study of nuclear receptor subfamily 4 group A member 1 (NR4A1) in rat kidney tissues; B: Quantitative real-time PCR of NR4A1 mRNA expression in rat kidney tissues, n = 3. ^aP < 0.05 vs control. CON: Control; DKD: Diabetic kidney disease; NR4A1: Nuclear receptor subfamily 4 group A member 1.