Glabridin and gymnemic acid alleviates choroid structural change and choriocapillaris impairment in diabetic rat’s eyes

Figure 5 Glabridin and gymnemic acid have the ability to reduce the amount of angiogenic cytokine, which is essential for the process of survival. Representative images of the immunohistochemical sections of the choroidal layer with specific cluster of differentiation (CD) 31 antibodies in rat eyes. Examples of immunoreactive CD31, particularly in the regions of the retinal pigment epithelial and choriocapillaris as well as in the walls of blood vessels (white arrowheads), were present in the diabetic group at 600 magnifications. Scale bar = 20 μm. DAPI: 4’,6-diamidino-2-phenylindole; CD: Cluster of differentiation; DM: Diabetic; DM + GB: Diabetic rats treated with glabridin 40 mg/kg body weight; DM + GM: Diabetic rats treated with gymnemic acid 400 mg/kg body weight; DM + GR: Diabetic rats treated with glyburide 4 mg/kg body weight.