Glabridin and gymnemic acid alleviates choroid structural change and choriocapillaris impairment in diabetic rat’s eyes

Figure 3 Glabridin and gymnemic acid can reduce a potent angiogenic cytokine. Representative images of the immunohistochemical sections of the choroidal layer with specific vascular endothelial growth factor (VEGF) antibodies in rat eyes. Examples of immunoreactive VEGF, particularly in the choriocapillaris and the retinal pigment epithelium (white arrowheads), were present in the diabetic group at 600 magnifications. Scale bar = 20 μm. VEGF: Vascular endothelial growth factor; DAPI: 4’,6-diamidino-2-phenylindole; DM: Diabetic; DM + GB: Diabetic rats treated with glabridin 40 mg/kg body weight; DM + GM: Diabetic rats treated with gymnemic acid 400 mg/kg body weight; DM + GR: Diabetic rats treated with glyburide 4 mg/kg body weight.