Glabridin and gymnemic acid alleviates choroid structural change and choriocapillaris impairment in diabetic rat’s eyes

Figure 2 The effect of glabridin and gymnemic acid on the thickness of the choroidal layer in five groups of rats at 8 weeks. ^aP < 0.001. ¹P calculated as representative graph presents the significant increases in the thickness of the choroidal layer in the diabetic group compared with the control rats. ²P calculated after supplementation with glabridin, gymnemic acid, and glyburide, the thickness of choroidal layer decreased in the diabetic rats treated with glabridin 40 mg/kg body weight, diabetic rats treated with gymnemic acid 400 mg/kg body weight, and diabetic rats treated with glyburide 4 mg/kg body weight groups compared with the diabetic rats. DM: Diabetic; DM + GB: Diabetic rats treated with glabridin 40 mg/kg body weight; DM + GM: Diabetic rats treated with gymnemic acid 400 mg/kg body weight; DM + GR: Diabetic rats treated with glyburide 4 mg/kg body weight.