Glabridin and gymnemic acid alleviates choroid structural change and choriocapillaris impairment in diabetic rat’s eyes

Figure 1 Glabridin and gymnemic acid have ability to reverse histopathological changes in the choroid thickness of diabetic rats. Light micrographs of the choroidal and scleral layers and the extra ocular muscle of the eye. The choroid and sclera can be separated by choroidoscleral junctions (black arrows). A-E: Hematoxylin eosin stained; F-J: Masson’s trichrome in all five groups of rats. The thickness of the choroidal layer in each group is presented with the white line. The choroidal layer is composed of choroid arteries (blue arrow heads). Changes in the histological characteristics of the choroidal layer were observed in the diabetic group, involving the thickness of the choroidal layer and the choroidal arterial wall, particularly in the region of the tunica adventitia (white roundness). Scale bar = 20 μm. SC: Scleral; DM: Diabetic; DM + GB: Diabetic rats treated with glabridin 40 mg/kg body weight; DM + GM: Diabetic rats treated with gymnemic acid 400 mg/kg body weight; DM + GR: Diabetic rats treated with glyburide 4 mg/kg body weight.