Effects of glycemic indicators on early neurological outcomes in patients with acute ischemic stroke treated with intravenous thrombolysis

Table 4 Multivariate logistical regression analyses depicting the association of glycemic indicators and early neurological outcomes in the patients with and without diabetes

Parameter	Early neurological deterioration			Early neurological improvement
	OR	95%CI	P value	OR	95%CI	P value
Patients with DM1
Admission hyperglycemia	1.954	1.061-3.601	0.032	0.723	0.356-1.468	0.369
Fasting blood glucose
First quartile	Reference	Reference	Reference	Reference	Reference	Reference
Second quartile	2.220	0.782-6.299	0.134	0.921	0.340-2.494	0.871
Third quartile	2.025	0.758-5.406	0.159	0.940	0.369-2.397	0.897
Fourth quartile	3.924	1.568-9.816	0.003	0.748	0.299-1.875	0.536
Fasting blood glucose
First quartile	Reference	Reference	Reference	Reference	Reference	Reference
Second quartile	3.620	1.743-7.734	0.002	1.932	0.973-6.910	0.063
Third quartile	2.826	1.143-6.990	0.025	1.203	0.470-3.078	0.699
Fourth quartile	5.744	2.410-9.831	0.001	1.536	0.567-4.162	0.398
Patients without DM2
Admission hyperglycemia	1.602	1.027-2.499	0.038	1.055	0.635-1.752	0.837
Fasting blood glucose
First quartile	Reference	Reference	Reference	Reference	Reference	Reference
Second quartile	1.035	0.551-1.944	0.914	0.671	0.373-1.207	0.183
Third quartile	1.646	0.894-3.033	0.110	0.746	0.399-1.393	0.357
Fourth quartile	1.873	0.984-3.565	0.056	0.739	0.359-1.520	0.411
Fasting blood glucose
First quartile	Reference	Reference	Reference	Reference	Reference	Reference
Second quartile	1.904	0.975-3.719	0.059	1.635	0.890-3.004	0.113
Third quartile	2.263	1.155-4.434	0.017	0.930	0.472-1.832	0.834
Fourth quartile	2.908	1.521-5.556	0.001	1.090	0.547-2.175	0.806

¹Adjustment by age, sex, atrial fibrillation, stroke subtype, initial National Institutes of Health Stroke Scale.

²Adjustment by age, atrial fibrillation, blood pressure, stroke subtype, initial National Institutes of Health Stroke Scale, systolic blood pressure, low-density lipoprotein.

Neither early neurological improvement nor early neurological deterioration group was the reference group. CI: Confidence interval; DM: Diabetes mellitus; OR: Odds ratio.