N6-methyladenosine methyltransferase Wilms tumor 1-associated protein impedes diabetic wound healing through epigenetically activating DNA methyltransferase 1

Figure 2 Knockdown of Wilms tumor 1-associated protein activates proliferation, invasion, and angiogenesis of human umbilical vein endothelial cells. Human umbilical vein endothelial cells were stimulated with high glucose and transfected with siWilms tumor 1-associated protein. A: Cell viability was measured using cell counting kit 8 assay; B: The in vitro angiogenesis was measured by tube formation assay; C: Cell migration was analyzed by Transwell assay; D: The relative RNA levels of RNA methyltransferases were measured by quantitative PCR assay; E: Migration of high glucose-stimulated human umbilical vein endothelial cells. ^aP < 0.05; ^cP < 0.001; HG: High glucose; WTAP: Wilms tumor 1-associated protein.