Triglyceride-glucose related indices as predictors for major adverse cardiovascular events and overall mortality in type-2 diabetes mellitus patients

Table 6 Additional predictive value of triglyceride-glucose related indices for major adverse cardiovascular events and total mortality

	AUC (95%CI)	P value	NRI (95%CI)	P value	IDI (95%CI)	P value
MACEs
Basic model	0.6264 (0.6131, 0.6396)		Reference		Reference
Basic model + TyG	0.6318 (0.6186, 0.6450)	0.0039	0.0660 (0.0380, 0.1000)	< 0.0001	0.0030 (0.0010, 0.0060)	< 0.0001
Basic model + TyG-WHtR	0.6344 (0.6213, 0.6475)	0.0012	0.0770 (0.0450, 0.1060)	< 0.0001	0.0040 (0.0020, 0.0070)	< 0.0001
Basic model + TyG-WC	0.6322 (0.6191, 0.6454)	0.0043	0.0610 (0.0280, 0.0850)	< 0.0001	0.0030 (0.0010, 0.0060)	< 0.0001
Total mortality
Basic model	0.6667 (0.6539, 0.6794)		Reference		Reference
Basic model + TyG	0.6683 (0.6556, 0.6811)	0.0324	0.0340 (0.0020, 0.0630)	0.0400	0.0010 (0.0000, 0.0020)	0.1200
Basic model + TyG-WHtR	0.6696 (0.6569, 0.6823)	0.0038	0.0520 (0.0200, 0.0800)	< 0.0001	0.0020 (0.0000, 0.0040)	0.0070
Basic model + TyG-WC	0.6701 (0.6574, 0.6829)	0.0025	0.0410 (0.0110, 0.0690)	< 0.0001	0.0020 (0.0000, 0.0050)	0.0070

Basic model: Sex, age, duration of diabetes, smoking, body mass index, glycated hemoglobin, systolic blood pressure, diastolic blood pressure, low-density lipoprotein cholesterol, previous hypertension and previous hyperlipidemia, insulins use. MACEs: Major adverse cardiovascular events; TyG: Triglyceride glucose; WHtR: Waist height ratio; WC: Waist circumference; AUC: Area under curve; NRI: Net reclassification index; IDI: Integrated discrimination improvement.