Plantamajoside improves type 2 diabetes mellitus pancreatic β-cell damage by inhibiting endoplasmic reticulum stress through Dnajc1 up-regulation

Figure 3 Validation of the impact of plantamajoside intervention on apoptosis and endoplasmic reticulum stress in high glucose + palmitic acid-induced pancreatic β-cells. A: Flow cytometry results indicate that plantamajoside (PMS) intervention reduced the rate of apoptosis; B-E: Western blot results showing that PMS intervention upregulated the expression of Bcl-2 and downregulated the expression of Bax and CytC; F-K: Western blot results revealing that PMS intervention upregulated the expression of Dnajc1 and downregulated the expression of ATF6, XBP1, Ddit3 (CHOP) and GRP78. n = 3 per group. ^aP < 0.05, ^bP < 0.01 vs the normal control group; ^cP < 0.05, ^dP < 0.01 vs the high glucose (HG) + palmitic acid (PA) group.