Islet β-cell function preservation by different anti-diabetic treatments in Chinese elderly patients with type 2 diabetes mellitus

Table 4 Changes of β-cell function after different anti-diabetic treatments according to disease duration

Treatment	Disease duration (years)	Fasting insulin (pmol/L/h)	Fasting C-peptide (nmol/L/h)	AUC insulin (pmol/L/h)	AUC C-peptide (nmol/L/h)
Ins	0-1	65.4 ± 6.6	0.88 ± 0.08	695.7 ± 105.5	5.58 ± 0.57
	1-5	104.0 ± 33.6	0.68 ± 0.05	731.0 ± 111.2	5.16 ± 0.43
	5-10	95.5 ± 28.9	0.69 ± 0.06	628.3 ± 125.0	4.22 ± 0.34
	10-20	72.6.0 ± 24.9	0.70 ± 0.07	550.6 ± 122.9	3.91 ± 0.37
	20-30	93.1 ± 31.6	0.73 ± 0.15	605.7 ± 131.7	3.68 ± 0.51
OAD	0-1	64.7 ± 5.8	0.87 ± 0.04	696.9 ± 54.6	6.14 ± 0.27
	1-5	77.0 ± 6.6	0.98 ± 0.07	761.1 ± 39.8	6.65 ± 0.25
	5-10	62.7 ± 3.4	0.88 ± 0.03	687.8 ± 40.1	6.05 ± 0.25
	10-20	98.8 ± 18.8	0.81 ± 0.03	740.1 ± 84.4	5.14 ± 0.20
	20-30	96.8 ± 26.1	1.00 ± 0.13	709.5 ± 139.4	5.74 ± 0.65
Ins + OAD	0-1	80.6 ± 13.6	0.80 ± 0.07	715.2 ± 95.9	5.12 ± 0.48
	1-5	76.6 ± 8.9	0.78 ± 0.03	597.1 ± 53.2	4.47 ± 0.23
	5-10	89.2 ± 17.3	0.66 ± 0.02	638.0 ± 92.7	3.85 ± 0.17
	10-20	84.4 ± 7.8	0.70 ± 0.05	533.9 ± 33.4	3.85 ± 0.16
	20-30	204.2 ± 93.2	0.75 ± 0.06	542.0 ± 67.6	3.94 ± 0.31
P value	0-1	0.631	0.095	0.805	0.002
	1-5	0.402	0.001	0.001	0.001
	5-10	0.369	0.001	0.002	0.001
	10-20	0.132	0.001	0.005	0.001
	20-30	0.161	0.041	0.039	0.002

Data were presented as mean ± SD. P value was derived from the One-Way ANOVA or Kruskal-Waillis test between the three groups according to similar disease durations. Ins: Insulin therapy; OAD: Oral anti-diabetes drugs; AUC: Area under the curve.