Effect of SPTLC1 on type 2 diabetes mellitus

Table 1 The clinical features of proband and family members

Features	Normal range	III-1 (proband)	IV-1	II-2
Gender		Male	Male	Female
Age at admission, years		44.00	19.00	68.00
Age at DM onset, years		42.00	17.00	53.00
Weight, kg		50.00	70.00	51.00
Height, cm		170.00	174.00	156.00
Waist, cm		71.00	82.00	87.00
BMI, kg/m2		17.30	23.12	20.96
SBP, mmHg		118.00	130.00	129.00
DBP, mmHg		90.00	85.00	68.00
FCP, ng/mL	0.81-1.89	1.04		1.16
2hCP, ng/mL		2.39		1.30
FINS, μU/L	4.00-12.00		12.65
2hINS, μU/L			83.15
HbA1c, %	3.60-6.00	12.6	10.80	10.40
TC, mmol/L	3.10-5.20	3.90	3.29	4.95
TG, mmol/L	0.56-1.70	0.95	1.01	0.93
HDL, mmol/L	1.00-1.55	1.06	0.89	1.21
LDL, mmol/L	1.90-3.10	2.45	1.84	3.03
Hs-CRP, mg/L	0.00-3.00	0.37	1.57	5.16
GADA	Negative	Negative	Negative
IAA	Negative	Negative	Negative
IA-2A	Negative	Negative	Negative
ICA	Negative	Negative	Negative
ACR, mg/g	0.00-30.00	16.85		25.66
Ketobodies in urine	Negative	Negative	Negative	Negative
DR	Negative	No	No	No

ACR: Albumin to creatinine ratio; BMI: Body mass index; CRP: C-reactive protein; DBP: Diastolic blood pressure; DM: Diabetes mellitus; DR: Diabetic retinopathy; FCP: Fasting C-peptide; FINS: Fasting insulin; GADA: Glutamic acid decarboxylase autoantibody; HbA1c: Hemoglobin A1c; HDL: High-density lipoprotein cholesterol; IA-2A: Protein tyrosine phosphatase autoantibody; IAA: Autoantibody against to insulin; ICA: Islet cell autoantibody; LDL: Low-density lipoprotein cholesterol; SBP: Systolic blood pressure; TC: Total cholesterol; TG: Triglyceride; 2hCP: 2-hour postprandial C-peptide; 2hINS: 2-hour postprandial insulin.