Electroacupuncture alleviates diabetic peripheral neuropathy through modulating mitochondrial biogenesis and suppressing oxidative stress

Figure 5 Effect of electroacupuncture on the expression of silent information regulator type 2 homolog-1/peroxisome proliferator-activated receptor-gamma coactivator-1α in sciatic nerve. A: Protein bands of silent information regulator type 2 homolog-1 (SIRT1), mitochondrial transcription factor A (TFAM), peroxisome proliferator-activated receptor-gamma coactivator-1α (PGC-1α), nuclear respiratory factor 1 (Nrf1), and nuclear factor erythroid 2-related factor 2 (Nrf2); B-F: Relative expression of SIRT1 (B), PGC-1α(C), TFAM (D), Nrf1 (E) and Nrf2 (F). β-tubulin was used as a loading control of SIRT1 and TFAM. β-actin was used as a loading control for PGC-1α, Nrf1, and Nrf2. (n = 3). ^aP < 0.05, ^bP < 0.01 vs control group; ^cP < 0.05, ^dP < 0.01 vs model group; ^eP < 0.05, ^fP < 0.01 vs electroacupuncture (EA) group.