Transcriptome and single-cell profiling of the mechanism of diabetic kidney disease

Figure 1 The 10 intersection genes were enriched in the NOD-like receptor signaling pathway. A: Volcano plot of differentially expressed genes (DEGs); B: Heatmap of DEGs; C: Venn diagram of the intersection of DEGs and NLRP3 inflammasome-associated genes; D-F: Gene Ontology analysis of the intersection genes, including molecular function, cellular components, and biological processes; G: Significantly enriched Kyoto Encyclopedia of Genes and Genomes pathway analysis of the intersecting genes; H: Protein-protein interaction network of DEGs. DEGs: Differentially expressed genes; NLRP3: NOD-like receptor thermal protein domain associated protein 3; NIRGs: NLRP3 inflammasome-associated genes; GO: Gene Ontology; BP: Biological process; CC: Cellular component; MF: Molecular function; KEGG: Kyoto Encyclopedia of Genes and Genomes; SIRT2: Sirtuin 2; CASP1: Caspase 1.