L-arginine administration exacerbates myocardial injury in diabetics via prooxidant and proinflammatory mechanisms along with myocardial structural disruption

Figure 6 Histopathology of rats’ heart (Masson trichrome stain). A: G1 = Control group; B: G2 = Normal rats received 0.5 g/kg/day of L-arginine (L-Arg); C: G3 = Normal rats received 1 g/kg/day of L-Arg; D: G4 = Normal rats received 1.5 g/kg/day of L-Arg; E: G5 = Diabetic group; F: G6 = Diabetic rats received 0.5 g/kg/day of L-Arg; G: G7 = Diabetic rats received 1 g/kg/day of L-Arg; H: G8 = Diabetic rats received 1.5 g/kg/day of L-Arg; I: Cardiac fibrosis. Results are presented as mean ± SEM (n = 6). ^aP < 0.05 vs the control group. ^bP < 0.05 vs the diabetic group. ^cP < 0.05 vs the diabetic + L-Arg 05 g/kg group. ^dP < 0.05 vs the diabetic + L-Arg 1 g/kg group.