L-arginine administration exacerbates myocardial injury in diabetics via prooxidant and proinflammatory mechanisms along with myocardial structural disruption

Figure 2 Analysis of biochemical parameters in normal and treated rat groups, whereas animal weights, alanine aminotransferase, aspartate aminotransferase, serum creatine kinase, serum cardiac troponin I, lactate dehydrogenase. A: Animal weights; B: Alanine aminotransferase; C: Aspartate aminotransferase; D: Serum creatine kinase; E: Serum cardiac troponin I; F: Lactate dehydrogenase. G1 = Control group, G2 = Normal rats received 0.5 g/kg/day of L-arginine (L-Arg), G3 = Normal rats received 1 g/kg/day of L-Arg, G4 = Normal rats received 1.5 g/kg/day of L-Arg, G5 = Diabetic group, G6 = Diabetic rats received 0.5 g/kg/day of L-Arg, G7 = Diabetic rats received 1 g/kg/day of L-Arg, G8 = Diabetic rats received 1.5 g/kg/day of L-Arg. The data presented as means ± SE (n = 12). ^aP < 0.05 vs the control group. ^bP < 0.05 vs the diabetic group. ^cP < 0.05 vs the diabetic + L-Arg 05 g/kg group. ^dP < 0.05 vs the diabetic + L-Arg 1 g/kg group. AST: Aspartate aminotransferase; ALT: Alanine aminotransferase; LDH: Lactate dehydrogenase.