Risk factors for developing osteoporosis in diabetic kidney disease and its correlation with calcium-phosphorus metabolism, FGF23, and Klotho

Table 2 Comparison of biochemical indicators and calcium-phosphorus metabolic indexes

	Normal (n= 55)	OP (n = 103)	t/χ2	P value
FBG (mmol/L)	8.32 ± 2.83	8.39 ± 2.31	0.167	0.867
HbA1c (%)	7.44 ± 2.10	7.59 ± 2.09	0.429	0.668
Scr (µmol/L)	93.42 ± 20.13	94.32 ± 21.38	0.257	0.797
eGFR (mL/min × 1.73 m2)	89.42 ± 20.31	80.74 ± 24.23	2.265	0.025
Alb (g/L)	34.29 ± 8.39	32.83 ± 7.36	1.131	0.260
25-(OH)-D3 (ng/mL)	37.42 ± 17.32	25.33 ± 9.27	5.723	< 0.0001
iPTH (pg/mL)	39.72 ± 18.42	72.43 ± 18.48	10.610	< 0.0001
Blood Ca (mmol/L)	2.21 ± 0.19	1.98 ± 0.34	4.640	< 0.0001
Blood P (mmol/L)	1.13 ± 0.17	1.37 ± 0.34	4.912	< 0.0001
Calcium-phosphorus product (mmol2/L2)	2.64 ± 0.32	3.11 ± 0.78	4.276	< 0.0001
24-hour urinary phosphate excretion (mmol/24 hour)	20.42 ± 9.45	14.32 ± 5.97	4.961	< 0.0001
Fractional excretion of phosphate (%)	12.42 ± 1.74	40.28 ± 7.42	27.408	< 0.0001
FGF23 (ng/L)	267.32 ± 48.42	358.79 ± 53.72	10.544	< 0.0001
Klotho (ng/L)	253.79 ± 0.48	352.91 ± 0.57	1098.0	< 0.0001

OP: Osteoporosis; FBG: Fasting blood glucose; HbA1c: Hemoglobin A1c; Scr: Serum creatinine; eGFR: Estimated glomerular filtration rate; Alb: Albumin; iPTH: Intact parathyroid hormone; Ca: Calcium; P: Phosphorus.