Bone marrow-derived mesenchymal stem cell-derived exosome-loaded miR-129-5p targets high-mobility group box 1 attenuates neurological-impairment after diabetic cerebral hemorrhage

Figure 5 Screening for microRNA. A: Heat maps showed microRNA content in bone marrow-derived mesenchymal stem cell-derived exosomes; B: Gene Ontology functional enrichment analysis; C: Kyoto Encyclopedia of Genes and Genomes pathway analysis; D: The expression of microRNA-129-5p in the intracerebral hemorrhage + diabetes mellitus mice and high glucose + hemin-treated BV2 was detected by quantitative polymerase chain reaction assay. The experimental data are expressed as mean ± SD. In vivo: ^aP < 0.05, control group vs intracerebral hemorrhage + diabetes mellitus group, t-test. In vitro: ^aP < 0.05, control group vs high glucose + hemin group, t-test. GO: Gene Ontology; TNF: Tumor necrosis factor; HG: High glucose; DM: Diabetes mellitus; ICH: Intracerebral hemorrhage.