Dexmedetomidine ameliorates diabetic intestinal injury by promoting the polarization of M2 macrophages through the MMP23B pathway

Figure 8 In vivo studies demonstrated that MMP23 knockout upregulates arginase-1 and interleukin-10. A-R: MMP23 knockout led to M2 polarization. After inducing diabetes with the diabetes treatment, the fluorescence intensity of arginase-1 (A-I) and interleukin-10 (J-R) significantly decreased compared with that before treatment; S and T: Indicating fluorescence intensity levels after MMP23 knockout treatment. Scale bar = 50 μm. ^cP < 0.001, ^dP < 0.0001. DB: Diabetes group; Arg-1: Arginase-1; IL-10: Interleukin-10.