Dexmedetomidine ameliorates diabetic intestinal injury by promoting the polarization of M2 macrophages through the MMP23B pathway

Figure 3 Functional and pathway enrichment. Functional and pathway enrichment analyses were conducted using DAVID to gain a comprehensive understanding of the role played by the 31 differentially expressed genes identified in the brain tissue dataset. A-C: Main identified pathways: Cellular hormone metabolic process, hormone metabolic process, digestion, response to toxic substance, retinol metabolic process, collagen-containing extracellular matrix, brush border, and cluster of actin-based cell projections. KEGG: Kyoto Encyclopedia of Genes and Genomes; BP: Biological process; CC: Cell composition; MF: Molecular function; GO:0034754: Cellular hormone metabolic process; GO:0042445: Hormone metabolic process; GO:0007586: Digestion; GO:0062023: Collagen-containing extracellular matrix; GO:0005903: Brush border; GO:0098862: Cluster of actin-based cell projections; GO:0016616: Oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; GO:0016614: Oxidoreductase activity, acting on CH-OH group of donors; GO:0004032: Alditol:NADP+ 1-oxidoreductase activity; hsa00982: Drug metabolism-cytochrome P450; hsa00980: Metabolism of xenobiotics by cytochrome P450; hsa00830: Retinol metabolism.