Corilagin alleviates podocyte injury in diabetic nephropathy by regulating autophagy via the SIRT1-AMPK pathway

Figure 8 Corilagin promotes hyperglycemia-induced podocyte autophagy via SIRT1. A: Cells were stained for LC3-II and nuclei. The nuclei of surviving cells were stained with DAPI and showed blue fluorescence. The cytoplasm of autophagic cells was stained for LC3-II and shows green fluorescence; B: Quantitative analysis of autophagic cells in each group; C: Real-time quantitative PCR was performed to determine the expression of autophagy-related proteins; D: Quantification analysis of LC3 II and p62 protein bands normalized to GAPDH. Data are presented as the mean ± SD. ^aP < 0.001 vs control group; ^bP < 0.001 vs HG group; ^cP < 0.001 vs HG + Cor group. HG: High glucose; Cor: Corilagin.