Corilagin alleviates podocyte injury in diabetic nephropathy by regulating autophagy via the SIRT1-AMPK pathway

Figure 3 Corilagin reduces apoptosis in kidney tissue of mice. A: Representative images of TUNEL staining in the kidney (magnification 200 ×); B: Quantification analysis of renal tissue apoptosis by calculating the percentage of TUNEL-positive cells; C and D: Real-time quantitative PCR was performed to determine the mRNA levels of BAX and BCL-2 in kidney tissue. GAPDH was used as the internal control. Data are presented as the mean ± SD (n = 8 in each group). ^aP < 0.001 vs control group; ^bP < 0.001 vs DN group. Cor: Corilagin; DN: Diabetic nephropathy.