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©The Author(s) 2024.
World J Diabetes. Sep 15, 2024; 15(9): 1874-1888
Published online Sep 15, 2024. doi: 10.4239/wjd.v15.i9.1874
Published online Sep 15, 2024. doi: 10.4239/wjd.v15.i9.1874
Limitations | Description | Future directions |
Variability in microbial composition | Individual differences in microbiome composition complicate standard treatment outcomes | Personalized microbiome interventions: Develop treatments based on individual microbiome assessments to optimize efficacy |
Lack of standardization | Inconsistencies in probiotic formulations affect study comparability and clinical applicability | Standardization of products: Establish regulations and standards for probiotic formulations to ensure quality and consistency |
Short-term focus | Most studies have short duration and do not address long-term safety and effectiveness | Longitudinal studies: Conduct long-term studies to assess the sustained effects and safety of microbiome-based interventions |
Incomplete mechanistic understanding | The pathways through which the microbiome influences diabetes are not fully elucidated | Mechanistic research: Deepen research into the biochemical interactions within the gut microbiome that affect diabetes pathogenesis and treatment |
Drug-microbiome interactions | Potential interactions between probiotics and anti-diabetic medications are not well understood | Interaction studies: Explore how probiotics interact with common diabetic medications to refine treatment protocols |
Regulatory hurdles | The global regulatory landscape for probiotics and microbiome therapies varies significantly | Harmonize regulations: Work toward an international consensus on the regulation of microbiome therapies to facilitate global research and application |
- Citation: Jeyaraman M, Mariappan T, Jeyaraman N, Muthu S, Ramasubramanian S, Santos GS, da Fonseca LF, Lana JF. Gut microbiome: A revolution in type II diabetes mellitus. World J Diabetes 2024; 15(9): 1874-1888
- URL: https://www.wjgnet.com/1948-9358/full/v15/i9/1874.htm
- DOI: https://dx.doi.org/10.4239/wjd.v15.i9.1874