Autoantibodies against beta cells to predict early insulin requirements in pediatric patients with clinically diagnosed type 2 diabetes

doi:10.4239/wjd.v15.i8.1717

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Aug 15, 2024 (publication date) through Nov 1, 2024

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World Journal of Diabetes

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1948-9358

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Diabetes. Aug 15, 2024; 15(8): 1717-1725
Published online Aug 15, 2024. doi: 10.4239/wjd.v15.i8.1717

Table 7 Estimation of risks according to antibodies

Variable	Odds ratio early insulin requirements (n = 132)
Variable	OR adj (95%CI)	P value
Anti-GAD65	2.42 (1.112- 5.303)	0.026
Anti-IA2	1.55 (0.859- 2.818)	0.101
Anti-Zn8T	7.32 (2.039-26.279)	0.002
Anti-GAD65 + Anti-IA2	3.34 (1.136- 9.814)	0.028
Anti-GAD65 + anti-Zn8T	4.35 (1.168-16.248)	0.028
Anti-IA2 + anti-Zn8T	5.34 (1.123-25.431)	0.035
Anti-GAD65 + Anti-IA2 + anti-Zn8T	5.34 (1.123-25.431)	0.035

Adjusted for age, body mass index, and time of evolution of diabetes. GAD65: Glutamic acid decarboxylase; IA2: Islet antigen 2; Zn8T: Zinc transporter 8.

Citation: Molina JM, Medina PG, Gomez RA, Herrera JR, Martínez NL, Hernández B, García Y. Autoantibodies against beta cells to predict early insulin requirements in pediatric patients with clinically diagnosed type 2 diabetes. World J Diabetes 2024; 15(8): 1717-1725
URL: https://www.wjgnet.com/1948-9358/full/v15/i8/1717.htm
DOI: https://dx.doi.org/10.4239/wjd.v15.i8.1717