Interactions between myoblasts and macrophages under high glucose milieus result in inflammatory response and impaired insulin sensitivity

Figure 2 Insulin resistance induced myofiber atrophy and pro-inflammatory M1 phenotype macrophages infiltration in skeletal muscle. A: Hematoxylin eosin (H&E) staining of skeletal muscle and the areas of Myofiber (Scale bar: 50 μm); B: The expression of F4/80, and the co-localization of F4/80 with CD86 and CD206 respectively in skeletal muscle detected by Immunofluorescence (Scale bar: 50 μm). Data are means ± SD, n = 6 per group. ^aP < 0.01 vs Con group. P values were calculated by two-tailed Student’s t-test. Con: Control group; IR: Insulin resistance group.