Interactions between myoblasts and macrophages under high glucose milieus result in inflammatory response and impaired insulin sensitivity

Figure 1 High-fat diet fed for 12 wk induces insulin resistance in mice. A: Body weight development of control group (Con group) and insulin resistance (IR) group mice during 12 wk fed; B: Fasting blood glucose of Con and IR group mice during 12 wk fed; C: Fasting insulin levels of Con and IR group mice fed for 12 wk; D: Homeostasis model assessment of IR of Con and IR group mice fed for 12 wk; E: Triglyceride, total cholesterol, high density lipoprotein-cholesterol, and low density lipoprotein-cholesterol concentration in serum in Con and IR group mice fed for 12 wk; F: Blood glucose values during intraperitoneal glucose tolerance tests of Con and IR group mice fed for 12 wk; G: Blood glucose values during insulin tolerance tests of Con and IR group mice fed for 12 wk. Data are means ± SD, n = 6 per group. ^aP < 0.01 vs Con group. P values were calculated by two-tailed Student’s t-test. Con: Control group; IR: Insulin resistance group; ITT: Insulin tolerance test; GTT: Glucose tolerance tests.