Network pharmacology and molecular dynamics study of the effect of the Astragalus-Coptis drug pair on diabetic kidney disease

Figure 1 Screening of Astragalus-Coptis drug pair common targets. A: Venn diagram illustrating the target genes associated with diabetic kidney disease (DKD); B: Venn diagram depicting the 273 common targets between the active ingredient targets and DKD targets; C: Volcano plot displaying differential gene expression patterns in DKD samples, where red and blue indicate upregulated and downregulated genes, respectively, while gray represents no significant difference; D: Heatmap presenting the expression profiles of these 50 differential gene expression analysis. Columns correspond to sample groups, while rows represent individual genes. The cyan Group A denotes normal samples, whereas the red Group B signifies DKD samples. OMIM: Online Mendelian Inheritance in Man database.