Glymphatic function and its influencing factors in different glucose metabolism states

Figure 4 The correlation between the diffusion tensor image analysis method along the perivascular space index and other clinical features. A: The left-side diffusion tensor image analysis method along the perivascular space (DTI-ALPS) index in the prediabetes group was positively correlated with 2-hour postprandial glucose (2hPG) (r = 0. 582, P = 0.009, 95%CI: 0.192 to 0.830); B and C:The left-side DTI-ALPS index in the prediabetes group was negatively correlated with total cholesterol (r = -0.567, P = 0.011, 95%CI: -0.831 to -0.152) and low-density lipoprotein (r = -0.545, P = 0.016, 95%CI: -0.720 to 0.235); D and E: The right-side DTI-ALPS index in the prediabetes group was negatively correlated with waist-to-hip ratio (r = -0. 495, P = 0.031, 95%CI: -0.784 to 0.017) and glycosylated hemoglobin (HbA1c) (r = -0.662, P = 0.002, 95%CI: -0.867 to -0.122); F and G: The mean DTI-ALPS index in the prediabetes group negatively correlated with waist-to-hip ratio (r = -0.467, P = 0.044, 95%CI: -0.770 to 0.067) and HbA1c (r = -0.725, P = 0.0004, 95%CI: -0.886 to -0.398); H:The mean DTI-ALPS index in the prediabetes group was positively correlated with 2hPG (r = 0.477, P = 0.039, 95%CI: -0.103 to 0.797); I: The left-side DTI-ALPS index in the type 2 diabetes mellitus (T2DM) group was positively correlated with height (r = 0.553, P = 0.009, 95%CI: -0.142 to 0.822); J: The left-side DTI-ALPS index in the T2DM group was negatively correlated with high-density lipoprotein (HDL) (r = -0.548, P = 0.010, 95%CI: -0.792 to -0.109); K: The right-side DTI-ALPS index in the T2DM group was positively correlated with height (r = 0.621, P = 0.003, 95%CI: 0.096 to 0.828); L: The mean DTI-ALPS index of the T2DM group was positively correlated with height (r = 0.651, P = 0.001, 95%CI: 0.016 to 0.853); M: The mean DTI-ALPS index in the T2DM group negatively correlated with HDL (r = -0.544, P = 0.010, 95%CI: -0.802 to -0.013). T2DM: Type 2 diabetes mellitus; NGM: Normal glucose metabolism; DTI-ALPS: Diffusion tensor image analysis method along the perivascular space; L-DTI-ALPS: Diffusion tensor image analysis method along the perivascular space index of the left cerebral hemisphere in prediabetes and type 2 diabetes mellitus; R-DTI-ALPS: Diffusion tensor image analysis method along the perivascular space index of the right cerebral hemisphere of prediabetes and type 2 diabetes mellitus; Mean-DTI-ALPS: Mean Diffusion tensor image analysis method along the perivascular space index in both cerebral hemispheres; 2hPG: 2-hour postprandial glucose; TC: Total cholesterol; LDL: Low-density lipoprotein; HbA1c: Glycosylated hemoglobin; HDL: High-density lipoprotein.