Evaluation of teplizumab's efficacy and safety in treatment of type 1 diabetes mellitus: A systematic review and meta-analysis

Table 3 Risk of bias assessment of included studies

	Herold et al[17]	Hagopian et al[18]	Herold et al[19]	Herold et al[20]	Herold et al[21]	Perdigoto et al[22]	Sherry et al[23]	Sims et al[24]
Did the study avoid inappropriate exclusions	Y	Y	Y	Y	Y	Y	Y	Y
Did all patients receive the same reference standard	Y	Y	Y	Y	Y	Y	Y	Y
Were all patients included in the analysis	N	N	N	N	N	N	N	N
Was the sample frame appropriate to address the target population	Y	Y	Y	Y	Y	Y	Y	Y
Were study participants sampled in an appropriate way	Y	Y	Y	Y	Y	Y	Y	Y
Were the study subjects and the setting described in detail	Y	Y	Y	Y	Y	Y	Y	Y
Were valid methods used for the identification of the condition	Y	Y	Y	Y	Y	Y	Y	Y
Was the condition measured in a standard, reliable way for all participants	Y	Y	Y	Y	Y	Y	Y	Y

Y: Yes; N: No.