Evaluation of teplizumab's efficacy and safety in treatment of type 1 diabetes mellitus: A systematic review and meta-analysis

Table 2 Brief summary of the included studies

Ref.	Year of publication	Journal of publication	Country of study	Study setting	Study design	Total number of participants (n)	Diagnosis	Age of patients	Teplizumab group (n)	Control group (n)	Duration of study	Sex (M/F)	Primary outcomes
Herold et al[17]	2002	The New England Journal of Medicine	United States	HIC	RCT	24	Type-1 diabetes	7-30 years	12	12	1 year	18/6	Positive outcomes: Lower insulin uses and decrease in value of HbA1c, Adverse events
Hagopian et al[18]	2013	Diabetes	Sweden	HIC	RCT	410	Type-1 diabetes	8-35 years	311	99	2 years	295/115	Positive outcomes: Change in area under the curve for C-peptide, lower insulin uses and decrease in value of HbA1c, Adverse events
Herold et al[19]	2013	Diabetologia	United States	HIC	RCT	58	Type-1 diabetes	12-15 years	31	27	1 year	30/28	Positive outcomes: Change in area under the curve for C-peptide, and decrease in value of HbA1c, Adverse events
Herold et al[20]	2019	New England Journal of medicine	United States	HIC	RCT	76	Type-1 diabetes	12-22 years	44	32	2 years	36/40	Positive outcomes: Decrease in value of HbA1c, Adverse events
Herold et al[21]	2023	Diabetes care	United States	HIC	RCT	609	Type-1 diabetes	8-35 years	375	234	1 year	370/239	Positive outcomes: Change in area under the curve for C-peptide, and decrease in value of HbA1c, Adverse events
Perdigoto et al[22]	2019	Diabetologia	United States	HIC	RCT	43	Type-1 diabetes	8-30 years	31	12	2 years	26/17	Positive outcomes: Change in area under the curve for C-peptide, and decrease in value of HbA1c, Adverse events
Sherry et al[23]	2011	Lancet	United States	HIC	RCT	763	Type-1 diabetes	8-35 years	513	99	2 years	325/438	Positive outcomes: Lower insulin uses and decrease in value of HbA1c, Adverse events
Sims et al[24]	2021	Science Translation medicine	United States	HIC	RCT	76	Type-1 diabetes	8-39 years	44	32	2 years	40/36	Positive outcomes: Change in area under the curve for C-peptide and decrease in value of HbA1c, Adverse events

HbA1c: Glycated haemoglobin A1c; RCT: Randomized controlled trial; M: Male; F: Female; HIC: High income countries.