Evaluation of teplizumab's efficacy and safety in treatment of type 1 diabetes mellitus: A systematic review and meta-analysis

Table 1 Database search strategy

Database	Search strategy
Scopus	11 “Type-1 Diabetes mellitus” OR “T1DM” OR “Teplizumab” OR “anti-CD3 monoclonal antibody”
	12 “Insulin” OR “Glycated hemoglobin A1c” OR “HbA1C” OR “C-peptide” OR “Adverse events” OR “Randomized controlled trials” OR “RCT” OR “Systematic review” OR “meta-analysis”
	13 11 AND 12
PubMed	11 “Type-1 Diabetes mellitus” OR “T1DM”(MeSH Terms)1 OR “Teplizumab”(all fields) OR “anti-CD3 monoclonal antibody”(all fields)
	12 “Insulin”(MeSH Terms) OR “Glycated hemoglobin A1c”(all fields) OR “HbA1C”(all fields) OR “C-peptide”(all fields) OR “Adverse events” OR “Randomized controlled trials”(all fields) OR “RCT”(all fields) OR “systematic review” OR “meta-analysis”
	13 11 AND 12
Embase	“Type-1 Diabetes mellitus”/ exp2 OR “TIDM”/ exp OR “Teplizumab”/exp OR “anti-CD3 monoclonal antibody”/exp
	12 “Insulin”/ exp OR “Glycated hemoglobin A1c” / exp OR “HbA1C”/exp OR “C-peptide”/exp OR “Adverse events”/exp OR “Randomized controlled trials”/exp OR “RCT”/exp OR “systematic review”/ exp OR “meta-analysis”
	13 11 AND 12
Cochrane library	11 (Type-1 Diabetes mellitus): Ti, ab, kw3 OR (T1DM): Ti, ab, kw OR (Teplizumab): Ti, ab, kw OR (anti-CD3 monoclonal antibody): Ti, ab, kw OR (Cortisol): Ti, ab, kw (Word variations have been searched)
	12 (Insulin): Ti, ab, kw OR (Glycated hemoglobin A1c): Ti, ab, kw OR (HbA1C): Ti, ab, kw or (C-peptide): Ti, ab, kw or (Adverse events): Ti, ab, kw or (Randomized controlled trials): Ti, ab, kw or (systematic review): Ti, ab, kw or (meta-analysis): Ti, ab, kw (Word variations have been searched)
	13 11 AND 12

¹MeSH terms: Medical subject headings.

²exp: Explosion in emtree- searching of selected subject terms and related subjects.

³ti, ab, kw: Either title or abstract or keyword fields.