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©The Author(s) 2024.
World J Diabetes. Jul 15, 2024; 15(7): 1603-1614
Published online Jul 15, 2024. doi: 10.4239/wjd.v15.i7.1603
Published online Jul 15, 2024. doi: 10.4239/wjd.v15.i7.1603
No. | Year | Study design | Setting | Department | Sample size | Intervention | Dose | Duration | Effect | Ref. |
1 | 2021 | Double-blind placebo | St. Michael’s Hospital, University of Toronto | Out patient’s department | 24 T2DM patients | American ginseng | 1 g/meal (3 g/d) | 8 wk | Decrease blood glucose, HbA1c, and systolic blood pressure and increase nitric oxide | [26] |
2 | 2020 | Randomized, placebo-controlled, two-center trial | Two university-affiliated centres (St. Michael’s Hospital Toronto, Canada, and KB Merkur Hospital, Zagreb, and Croatia) | 80 participants with diagnosed T2D and hypertension | American ginseng extract and Rg3- enriched Korean ginseng extract [f 1.50 g/d AG and 0.75 g/d Rg3-KRG standardized extracts (extracted to contain 75 mg of ginsenoside Rg3 and 375 mg total ginsenosides)] | 2.25 g 3 times daily | 12 wk | Reduce end-systolic pressure (-6.60 mmHg ± 2.50 mmHg | [27] | |
3 | 2018 | Double-blinded, randomized, placebo-controlled trial | Diabetes PRAXIS Rathausallee, Duisburg, Germany | Specialized medical office for diabetology | 42 hypertensive patients with T2D | Flavanol-rich cocoa | 2.5 g/d | 12 wk | Reduce HOMA-IR and blood cholesterol level | [28] |
4 | 2018 | Randomized, placebo-controlled trial | Iranian Diabetes Society and Endocrine Research Center, Institute of Endocrinology and Metabolism, Iran University of Medical Sciences | Out patients department | 62 T2DM patients with at least one year of diabetic history | M. officinalis capsules | 700 mg/d | 12 wk | Reduce FBS, HbA1c, Insulin (min/mL), HOMA-b cell (%), hs-CRP (mg/L) | [29] |
5 | 2019 | Randomized, single-blind controlled trial | Shiraz Heart Center Outpatient Clinic affiliated with the Shiraz University of Medical Sciences, Shiraz, Iran | Out patients department | 75 metabolic syndrome patients | Sesame oil enriched with vit E group | 30 mL/d sesame oil + 400 mg vit E powder | 2 wk | Reductions in serum total cholesterol, triglycerides, FBG, HOMA-IR, MDA, hs-CRP, HDL-C systolic and diastolic BP | [30] |
6 | 2019 | Randomized, double-blinded, placebo-controlled trial | Cardiology clinic affiliated to Kashan University of Medical Sciences (KAUMS), Kashan, Iran | Out patients department | 90 T2D patients | Flaxseed oil and fish oil | 1000 mg of flaxseed oil, as the source of omega-3 fatty acids, containing 400 mg of ALA (n = 30) or 1000 mg of fish oil containing 250 mg of EPA and 150 mg of DHA | 12 wk | Reduce high-sensitivity CRP significant increase in total nitrite al antioxidant capacity | [31] |
7 | 2020 | Randomized double-blind clinical trial | Diabetes Control Center of Sabzevar Iran | Out patients department | 50 participants with diagnosed T2D | N. Sativa oil | 1000 mg N. Sativa oil as two capsules, each containing 500 mg N. Sativa oil, daily | 8 wk | Decrease FBS, triglyceride, total cholesterol, low-density lipoprotein cholesterol, serum hs-CRP, mdaand increase in serum level of high-density lipoprotein cholesterol | [32] |
8 | 2020 | Random assignment, parallel-group, single-center, double-blind, placebo-controlled design | Nizam’s Institute of Medical Sciences, Hyderabad | Out patients department | 74 T2DM patients | T. chebula | T. chebula 250 mg, T. chebula 500 mg | Twice daily for 12 wk | Improves endothelial function (reflection index), GSH, MDA, hs-CRP, total cholesterol, HDL, LDL, HbA1c | [33] |
9 | 2020 | Randomized, double-blind, placebo-controlled, cross-over intervention study | Diabetic and general medical clinics of the Prince of Wales Hospital, the teaching hospital of The Chinese University of Hong Kong, Shatin, Hong Kong | Out patients department | 20 T2D patients | Bilberry (Vaccinium myrtillus L.) | 1.4 g/d of extract) daily | 4 wk | Improves glycaemic control by HbA1c and Random blood sugar | [34] |
- Citation: Shrivastav D, Kumbhakar SK, Srivastava S, Singh DD. Natural product-based treatment potential for type 2 diabetes mellitus and cardiovascular disease. World J Diabetes 2024; 15(7): 1603-1614
- URL: https://www.wjgnet.com/1948-9358/full/v15/i7/1603.htm
- DOI: https://dx.doi.org/10.4239/wjd.v15.i7.1603