Network pharmacology and molecular dynamics study of the effect of the Astragalus-Coptis drug pair on diabetic kidney disease

Table 5 Analysis of topological parameters of key targets

Name	Degree centrality	Betweenness centrality	Closeness centrality	Degree
AKT1	155	6135.22026848002	0.00258397932816537	46
EGFR	127	2630.66165751648	0.00239234449760765	44
TNF	155	6936.3437260436	0.00257069408740359	43
SRC	129	3308.84927642964	0.00240384615384615	43
JUN	117	1696.42973120389	0.00232018561484918	43
CASP3	116	2086.85812276904	0.00233644859813084	43
MAPK3	119	2232.21929446136	0.00233100233100233	43
HSP90AA1	124	3622.00791458381	0.00235849056603773	41
STAT3	123	1881.06728458254	0.00234192037470726	40
ESR1	102	1938.43441498511	0.00224215246636771	38